赣南医学院学报Issue(3)：346-348,356,4.
Caspase-9在乳腺浸润性导管癌组织中的表达及其临床意义
Expression of Caspase-9 in breast infiltrating ductal carcinoma and its clinical significance
韦兴中 1陈朝华2
作者信息
- 1. 广西中医药大学附属瑞康医院肝胆腺体外科
- 2. 广西中医药大学，广西 南宁 530001
- 折叠
摘要
Abstract
Objectiye:To investigate the expression of Caspase-9 protein in breast infiltrating ductal carcinoma(IDC)and its clinical significance. Methods:The expression of Caspase-9 was detected by streptavidin-perosidase(SP)with tissues of thirty-eight cases of IDC and thirty-two cases of fibroadenoma,including normal tissues adjacent to tumor. Positive ex-pression of Caspase-9 relation with clinicopathological factors such as age,tumor size,lymph node metastasis were ob-served. Furthermore,clinical stage and histopathologic grade were explored in IDC. Results:The expression of Caspase-9 in IDC tissues and fibroadenoma tissues were lower than that in adjacent normal tissues( < 0. 05). Meanwhile,the IDC tissues was significantly down-regulated( < 0. 01). The expression of Caspase-9 was independent of clinicopathological parameters,such as age,tumor size,lymph node metastasis( > 0. 05). However,It had obvious negative correlation with clinical stage and histopathologic grade( < 0. 01). Conclusion:The lower expression of Caspase-9 closely correlates to the progress of breast infiltrating ductal carcinoma. The index greatly contributes to judgment of prognosis of breast infiltra-ting ductal carcinoma. Indicating that Caspase-9 might be used as a tumor biomarker and a potential therapeutic target for inhibiting the invasive of breast infiltrating ductal carcinoma.关键词
乳腺浸润性导管癌/半胱氨酸天门冬氨酸特异的蛋白酶 9/凋亡Key words
breast neoplasms/Caspase-9/apoptosis分类
医药卫生引用本文复制引用
韦兴中,陈朝华..Caspase-9在乳腺浸润性导管癌组织中的表达及其临床意义[J].赣南医学院学报,2014,(3):346-348,356,4.
