赣南医学院学报Issue(3)：381-383,3.
右美托咪定滴鼻预处理对全麻诱导期依托咪酯不良反应的影响
Effects of intranasal dexmedetomidine pretreatment on induction of general anesthesia with etomidate
陈金仙 1顾晓霞 1蔡树云 1刘奕君 1杨引1
作者信息
- 1. 广东医学院附属医院麻醉科，广东 湛江 524001
- 折叠
摘要
Abstract
Objectiye:To investigate the effects of etomidate injection pain and myoclonus given intranasal dexmedetomi-dine premedication on the induction of gereral anesthesia. Methods:Sixty cases undergone operation were randomly allo-cated to each group. Intranasal administrated dexmedetomidine1. 0 μg·kg - 1(group D n = 30)or given same volume of saline( group N n = 30)30 min before surgery. Blood pressure(BP),heart rate(HR),oxygen saturation(SPO2 )were recorded before drug(T0 ),to etomidate before(T1 )and to 1 min(T2 )、2 min(T3 )after etomidate. Scoring method used words(VRS)for etomidate injection pain score;observed and recorded myoclonus occurrence within 2 min after in-travenous etomidate. Results:There were no differences between two groups in all indexes before drug( > 0. 05). The SBP,HR,the VRS scores and myoclonus occurrence of group D were significantly lower than that of group N after drug(< 0. 05). SPO2 had no statistical significance between the two groups before and after drug( > 0. 05). Conclusions:These results suggest that the intranasal administration of dexmedetomidine in patients before operation is a safe and effec-tive preoperation medication,Not only can effectively reduce etomidate injection pain,but also significantly reduce myoc-lonus occurrence induced by etomidate to provide a more stable hemodynamic conditions.关键词
滴鼻预处理/右美托咪定/依托咪酯/肌阵挛/注射痛Key words
Pretreatment/Dexmedetomidine/Etomidate myoclonic/Injection pain分类
医药卫生引用本文复制引用
陈金仙,顾晓霞,蔡树云,刘奕君,杨引..右美托咪定滴鼻预处理对全麻诱导期依托咪酯不良反应的影响[J].赣南医学院学报,2014,(3):381-383,3.
