摘要
Abstract
Objective:To investigate the clinical efficacy of small doses of glucocorticoid combined with azithro-mycin in treating pediatric mycoplasmal pneumonia. Methods:Three hundred cases of mycoplasma pneumonia ped-iatric patients admitted to Beijing Huairou Hospital from January 2011 to January 2014 were randomly divided into two groups.Patients in the control group (n=150)were treated with injection of azithromycin 10 mg·kg-1 ·d-1 intravenously. In the observation group (n=150),patients received the treatment of injection of azithromycin 10 mg·kg-1 ·d-1 and a low dose of methylprednisolone sodium succinate 0.2 mg·kg-1 ·d-1 intravenously. Af-ter 7 days of treatment,blood was sampled to determine the levels of CD4+,CD8+,C-reactive protein (CRP), erythrocyte sedimentation rate (ESR),tumor necrosis factor-α(TNF-α),interleukin-2 (IL-2),IL-6. The time of improvement of symptoms and signs were also observed. Results:Compared to single azithromycin treatment,az-ithromycin combined with low dose of methylprednisolone sodium succinate could lower the temperature faster, shorten the cough disappearance time,rales disappearance time and hospital stay time,reduce the level of CD8+(all P<0.05),increased CD4+/CD8+ levels (P<0.01),and reduce CRP,ESR,TNF-α,IL-2,IL-6 levels (P<0.05). The symptoms and signs of patients in the observation group disappeared earlier than that of the con-trol group,with a higher effective rate(P<0.05). The recovery rates were 82.0% and 56.7%,and the rates of complications were 2.7% and 1 9.3% in the observation group and control group,respectively,and the differences were significant (P<0.05).Conclusions:Treatment with small doses of glucocorticoid combined with azithromy-cin can alleviate symptoms and signs,shorten the treatment course with better curative effects and less complica-tions in pediatric myocoplasmal pneumonia.关键词
糖皮质激素/阿奇霉素/支原体肺炎/炎性因子Key words
Small doses of glucocorticoids/Azithromycin/Mycoplasma pneumonia/Inflammatory cytokines
