甘肃医药2015，Vol.34Issue(5)：330-333,4.
胃癌EGFR基因突变的研究
Study on the correlation between EGFR gene mutation in gastric carcinoma
樊平 1李翔 1田国庆 1王晓明1
作者信息
- 1. 733000 甘肃 武威,甘肃省武威肿瘤医院病理科
- 折叠
摘要
Abstract
Objective:To detect mutations of epidermal growth factor receptor(EGFR) gene in gastric carcinoma, and to characterize the important role of EGFR mutation, clinicopathological parameters in GC. Methods:Polymerase chain reaction-single strand conformation polymorphism analysis and DNA sequencing technology for EGFR mutations of exons 18-21 of 105 cases in GC. Results: There were 3 cases were detected mutation and the rate was 2.86%;which of two cases in exon 19 deletion mutation;one case in exon 21 point mutation. Conclusion:EGFR gene mutations in gastric carcinoma organizations were not frequent events;the cases of EGFR gene mutations in gastric carcinoma may be had stronger ability of invasion and metastasis.关键词
胃癌/EGFR/基因突变Key words
gastric carcinoma/EGFR/gene mutation引用本文复制引用
樊平,李翔,田国庆,王晓明..胃癌EGFR基因突变的研究[J].甘肃医药,2015,34(5):330-333,4.
