广东药学院学报Issue(4)：395-398,4.DOI:10.3969/j.issn.1006-8783.2014.04.001
参芎滴丸制备工艺及有效成分含量测定方法的研究
Study on preparation and determination of Shenxiong dropping pills
摘要
Abstract
Objective To study the preparation of Shenxiong dropping pills and establish a method for the determination of ginsenoside Rg1 , ginsenoside Re. Methods On the basis of preliminary experiment, the formulation technology was selected among sort of the ratio of extractum to matrix, component of matrix, temperature of refrigerant and dropping distance,and all the procedure was evaluated by the appearance quality, disintegration time and weight variance of dropping pills as the evaluation indexes by means of orthogonal experimental method. Ginsenoside Rg1 ,and ginsenoside Re were determined by HPLC. Results The optimized preparation was as follows:PEG4000 to PEG6000(2∶1)was used as matrix with the extractum to matrix at 1∶3, the temperature of refrigerant was 8-10℃ and the dropping distance was 8 cm. The linear range of ginsenoside Rg1 was 0.203 5-6.105 μg,and the linear range of ginsenoside Re was 0.200 5-6.015 μg(r=0. 999 9). The average recovery of ginsenoside Rg1 was 100. 79%, RSD was 1. 14%( n=6 ) , and the average recovery of ginsenoside Re was 99.93%,RSD was 1.72%( n=6) . Conclusion The preparation is reasonable and feasible, and the determination method is sample,accurate and rapid with good reproducibility,which can be used in the preparation and the quality control of Shenxiong dropping pills.关键词
参芎滴丸/制备工艺/高效液相色谱法/人参皂苷Rg1/人参皂苷Re/含量测定Key words
Shenxiong dropping pills/preparation/HPLC/ginsenoside Rg1/ginsenoside Re/determination分类
医药卫生引用本文复制引用
吉国辉,李勇,朱家校,江斌,何伟..参芎滴丸制备工艺及有效成分含量测定方法的研究[J].广东药学院学报,2014,(4):395-398,4.基金项目
广东省科技计划项目(2011J4300059) （2011J4300059）
广东省中医药建设中医药强省重点科研项目(20123012) （20123012）
