广东药学院学报Issue(4)：501-504,4.DOI:10.3969/j.issn.1006-8783.2014.04.027
乏氧诱导因子-1α在鼻咽癌细胞表达及其与预后的关系
Expression of hypoxia inducible factor-1 alpha in nasopharyngeal cancer cells and its relationship with disease prognosis
蓝玉宏 1邵汛帆 2白力 1江晓聪 3谢福川3
作者信息
- 1. 广州医科大学附属肿瘤医院 放疗科，广东 广州510095
- 2. 广东惠州中心人民医院 肿瘤放射治疗中心，广东 惠州516001
- 3. 广东惠州中心人民医院 肿瘤放射治疗中心，广东 惠州516001
- 折叠
摘要
Abstract
Objective To evaluate the expression of hypoxia-inducible factor-1 alpha ( HIF-1α) in nasopharyngeal cancer cells and its relationship with disease prognosis. Methods 200 patients with nasopharyngeal carcinoma( NPC) in our hospital were collected. The expression of HIF-1αwas detected by immunohistochemistry. The relationship of the HIF-1α expression with disease prognosis was analyzed. Results The number of HIF-1α positive expression was 151 cases ( 75. 5%) , and the number of HIF-1αnegative expression was 49 cases ( 24. 5%) . For stage Ⅰ and Ⅱ patients, the curative effects was no difference between HIF-1α positive and negative expression groups. For stage Ⅲ and Ⅳa patients, the complete tumor regression rate in HIF-1α positive and negative expression groups after treatment was (85. 9%and 80.4%) and(91.7%and 84.6%),respectively,and the difference was statistically significant. The local control rate after 2 years of treatment in HIF-1α positive group ( 74. 6% and 69. 6%) was significantly lower than HIF-1α negative expression group(87.5% and 76.9%). The survival rate after 2 years of treatment in HIF-1α positive expression group ( 84. 5% and 76. 1%) was significantly lower than HIF-1αnegative expression group(95.8%and 84.6%). Conclusion HIF-1αis positively expressed in most of NPC,which is correlated with poor prognosis of stage Ⅲ and Ⅳa patients.关键词
乏氧诱导因子-1α/鼻咽癌细胞/表达/预后Key words
HIF-1 alpha/nasopharyngeal cancer cell/expression/prognosis分类
医药卫生引用本文复制引用
蓝玉宏,邵汛帆,白力,江晓聪,谢福川..乏氧诱导因子-1α在鼻咽癌细胞表达及其与预后的关系[J].广东药学院学报,2014,(4):501-504,4.
