广东药学院学报Issue(6)：671-674,4.DOI:10.3969/j.issn.1006-8783.2014.06.001
表面活性剂及高分子物质对头孢呋辛酯溶解特性的影响
Effect of surfactants and polymers on solubilization of cefuroxime axetil
摘要
Abstract
Objective To determine the saturated solubility of cefuroxime axetil and study the effect of different surfactants and polymers on solubilization of cefuroxime axetil. Methods Cefuroxime axetil solution was prepared by using surfactants and various water-soluble polymers with different concentration including sodium dodecyl sulfate(SDS), poloxamer 188, PVP K30, methyl cellulose (MC), hydroxypropyl methylcellulose ( HPMC-E3、E5、E15、K4M、K15M、K100M ) . The maximum solubility of cefuroxime axetil was determined by UV spectrophotometry. Results The maximum solubility of cefuroxime axetil with the water-soluble polymers concentration range 0.1-2.0 mg·mL-1 was as follows:0.62 mg·mL-1 [ρ( SDS)=2.0 mg·mL-1 ] ,1.09 mg· mL-1[ρPVP K30)=2.0 mg·mL-1],0.54 mg·mL-1[ρ(F68)=2.0 mg·mL-1],1.48 mg·mL-1[ρ(HPMC)=1.0 mg·mL-1],1.23 mg·mL-1[ρ(MC)= 1.0 mg·mL-1]. Conclusion Cefuroxime axetil is a drug with little solubility. HPMC K100M with the concentration of 1.0 mg·mL-1 or HPMC K4M with the concentration of 0. 5 mg · mL-1 can change the behavior of drug crystallization and may be the most suitable solubilizer to cefuroxime axetil.关键词
头孢呋辛酯/高分子物质/表面活性剂/增溶作用/抑制作用Key words
cefuroxime axetil/polymers/surfactants/solubilization/inhibition分类
医药卫生引用本文复制引用
郭波红,冯小菊,张可擎,晋晨晨..表面活性剂及高分子物质对头孢呋辛酯溶解特性的影响[J].广东药学院学报,2014,(6):671-674,4.基金项目
国家自然科学基金项目(81403111) （81403111）
广东省自然科学基金项目( S2011040003133) （ S2011040003133）
