摘要
Abstract
OBJECTIVE: To approach the curative effect of metoprolol sustained -release tablets on cardiac function and heart rate variability in patients with chronic heart failure .METHODS: 62 patients with chronic heart failure ( CHF) were randomly divid-ed into the observation group (n=32) and control group (n=30).The observation group received additional metoprolol sustained -release tablets and the control group were randomly treated routine therapy .After 12 months the changes of total effective rate , blood pressure, heart rate, left ventricular eject fraction (LVEF), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), N-terminal pro-brain natriuretic peptide (NT-proBNP) and heart rate variability (HRV) before and after treatment were compared in this two groups .RESULTS: Total effective rate, heart rate, left ventricular eject fraction ( LVEF) and heart rate variability ( HRV) in depression group were higher than those in control group .But left ventricular end -di-astolic volume (LVEDV), left ventricular end -systolic volume (LVESV) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were significantly lower .There were significantly statistical difference .CONCLUSIONS: Extra use of metoprolol sustained-release tablets combined with routine therapy can effectively increase the therapeutic effect , significantly improve ventricular remode-ling, cardiac function and heart rate variability , and enhance patients ’ life quality, which is helpful to secondary prevention of pa-tients with CHF .关键词
美托洛尔缓释片/慢性心力衰竭/心率变异性/心功能Key words
Metoprolol sustained release tablet/Chronic heart failure/Heart rate variability/Cardiac function
