国际老年医学杂志Issue(5)：200-202,241,4.DOI:10.3969/j.issn.1674-7593.2014.05.003
阿尔茨海默病精神障碍与叶酸和维生素B12的相关性
Correlations among Alzheimer’ s Disease, Folate and Vitamin B12
王金东 1郑占杰 1孔伶俐 1周田田 1崔维珍1
作者信息
- 1. 青岛市精神卫生中心，青岛 266034 中国
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the correlation among folate, vitamin B12 and behaviral and psychological symptoms of dementia (BPSD). METHODS: Folate and vitamin B12 were measured in 77 patients with Alzheimer disease (AD). BPSD group was 40 cases, non-BPSD group was 37cases and 39 persons were normal controls. The correlation among folate, vitamin B12 levels, BPSD and cognitive impairment were analyzed. RESULTS: ①The level of folate was significantly lower in BPSD and non -BPSD group than that in the normal group (P<0. 05). But there was no significantly differance in BPSD and non BPSD group (P>0. 05).②The vitamin B12 levels were significantly lower in BPSD and non-BPSD group than that in the normal group, and the level of it in BPSD group was significantly lower than that in non-BPSD group (P<0. 01). There was a positive relation between vitamin B12 lev-els and cognitive decline of dementia ( r =0. 441,P <0. 01). CONCLUTION: The low levels of folate and vitamin B12are related to the disorder of BPSD.关键词
阿尔茨海默病/精神障碍/叶酸/维生素B12Key words
Behaviral and psychological symptoms of dementia/Folate/Vitamin B12引用本文复制引用
王金东,郑占杰,孔伶俐,周田田,崔维珍..阿尔茨海默病精神障碍与叶酸和维生素B12的相关性[J].国际老年医学杂志,2014,(5):200-202,241,4.
