国际老年医学杂志Issue(4)：187-190,4.DOI:10.3969/j.issn.1674-7593.2015.04.012
PI-3 K/Akt信号转导通路在神经系统疾病中的研究进展
Research Progress in Phosphatidylinositol 3 Kinase/Protein Kinese B (PI-3 K/Akt) Signal Transduction Pathway and Nervous System Diseases
李小梅 1刘红 1王玉芬1
作者信息
- 1. 山西省长治医学院附属和平医院，长治 046000 中国
- 折叠
摘要
Abstract
The phosphatidylinositol 3 kinase/protein kinase B (PI-3K/Akt) signal transduction pathway is an important signal transduction pathway in cells and plays an important biological role in the apoptosis, proliferation, surviral of cell and changes of cy-toskeleton. And among them the regulation about cell apoptosis and survival is particalarly important. Cell apoptosis has participated in the courses of the occurrence and development of many nervous system disease. The research in recent years indicates that the acti-vation of the pathway has certain protective role of the nerve. The research of endogenous neural protection mechanism of PI-3K/Akt/GSK3 β signal pathway is expected to provide new theoretical basis for the treatment of nervous system diseases.关键词
磷脂酰肌醇-3-激酶/蛋白激酶B/信号转导通路/凋亡/神经系统疾病Key words
Phosphatidylinositol 3-kinase/Protein linase B/Signal transduction pathway/Apotosis/Nervous system disease引用本文复制引用
李小梅,刘红,王玉芬..PI-3 K/Akt信号转导通路在神经系统疾病中的研究进展[J].国际老年医学杂志,2015,(4):187-190,4.
