国际妇产科学杂志Issue(2)：132-136,5.
人乳头瘤病毒衣壳蛋白与宫颈病变
Human Papillomavirus′ Capsid Proteins and Cervical Lesions
黄成琳 1张淑兰1
作者信息
- 1. 110004 沈阳，中国医科大学附属盛京医院妇产科
- 折叠
摘要
Abstract
Cervical cancer seriously endangers women′s health,and human papillomavirus (HPV) is considered to be the primary cause. Doctors have been striving to find an effective diagnostic method for judging cervical lesions level and predicting its prognosis. HPV capsid proteins comprise the major capsid protein (L1 capsid protein) and the minor capsid protein (L2 capsid protein),and these two proteins play an important role in assembling into virus particles,trafficking HPV to the cell,and causing the host′s immune reactions. In recent years,studies have shown that the L1 capsid protein can be used to predict the progress and subsidence of cervical lesions. HPV prophylactic vaccines ,which are exploited on the basis of the L1 and L2 capsid protein,are proved to get a good preventive effect in clinical trials. This paper reviews the biological characteristics of HPV and researches progress on HPV capsid protein in cervical lesions in recent years.关键词
乳头状瘤病毒科/子宫颈/宫颈上皮内瘤样病变/活组织检查/L1壳蛋白/L2壳蛋白/免疫组织化学Key words
Papillomaviridae/Cervix uteri/Cervical intraepithelial neoplasia/Biopsy/L1 capsid protein/L2 capsid protein/Immunohistochemistry引用本文复制引用
黄成琳,张淑兰..人乳头瘤病毒衣壳蛋白与宫颈病变[J].国际妇产科学杂志,2014,(2):132-136,5.
