国际妇产科学杂志Issue(3)：236-239,4.
卵巢癌的DNA甲基化研究进展
Progress of DNA Methylation Changes in Ovarian Cancer
丁一 1龚晓明1
作者信息
- 1. 200020 上海，同济大学附属第一妇婴保健院
- 折叠
摘要
Abstract
Ovarian cancers are the most common gynecological neoplasms ,which has the highest mortality rate of cancers of the reproductive organs,because of lack of effective early diagnostic tool. DNA methylation is the first epigenetic changes discovered by human. Methlation of RASSF1A、BRCA1 and hMLH1 genes play an important role in the development of ovarian cancers. Detection of these genes could help early cancer diagnosis. However, some DNA methylation, like hMLH1, decline the sensitivity of chemotherapy drugs to tumor cells. Demethylation drugs which can reexpress those genes may improve the effect of chemotherapy and prognosis. In this review,we have summarized the newest researchs of DNA methylation changes in ovarian cancer.关键词
DNA甲基化/卵巢肿瘤/癌/诊断/治疗Key words
DNA methylation/Ovarian neoplasms/Carcinoma/Diagnosis/Therapy引用本文复制引用
丁一,龚晓明..卵巢癌的DNA甲基化研究进展[J].国际妇产科学杂志,2014,(3):236-239,4.
