国际妇产科学杂志Issue(3)：267-271,5.
加德纳菌生物膜在难治性细菌性阴道病中的研究
Study of Refractory Bacterial Vaginosis with the Gardnerella Vaginalis Biofilm
摘要
Abstract
Bacterial vaginosis (BV) can increase susceptibility of women to pelvic inflammatory disease,adverse pregnancy outcome and the risk of acquiring sexually transmitted diseases. Because of the factors causing BV and recurrent BV are complex,its etiology or pathogenesis still remains elusive. This review summarizes the microbiology and pathophysiology aspects of BV to enhance understanding of the vaginal microbiota ,which is characterized by the depletion of hydrogen peroxide-producing lactobacilli species and aggregation of bacterial vaginosis-associated bacteria (BVAB). Bacterial biofilm,formed by Gardnerella vaginalis in particular colonizes and adheres on the vaginal epithelium ,can′t be completely eradicated by host immune system or antibiotics,contributing to the chronic and recalcitrant infection. Further outlines on the current clinical therapy and the need to cater to specific biofilm eradication treatment to minimize its recurrence.关键词
阴道病,细菌性/抗药性,微生物/抗药性,细菌/加德那菌,阴道/生物膜Key words
Vaginosis,bacterial/Drug resistance,microbial/Drug resistance,bacterial/Gardnerella vaginalis/Biofilms引用本文复制引用
余竑敏,苏婷婷,隋龙..加德纳菌生物膜在难治性细菌性阴道病中的研究[J].国际妇产科学杂志,2014,(3):267-271,5.基金项目
上海市科委医学引导类项目 （）
