国际妇产科学杂志Issue(3)：304-306,3.
紫杉醇联合奥沙利铂治疗复发性或晚期宫颈癌临床疗效分析
Analysis of the Clinical Effects about Paclitaxel Plus Oxaliplatin in Treatment of Recurrent or Advanced Cervical Cancer
田秀兰 1翟建军 1冯碧波 1王慧香1
作者信息
- 1. 100176 首都医科大学附属北京同仁医院妇产科
- 折叠
摘要
Abstract
Objective:To investigate the clinical efficacy and adverse reactions of paclitaxel plus oxaliplatin in the treatment of recurrent or advanced cervical cancer. Methods:32 patients of recurrent or advanced cervical cancer were given the chemotherapy of paclitaxel plus oxaliplatin :the dose of paclitaxel was 150 mg/m2 intravenous infusion≥3 h in the first day,and the dose of oxaliplatin was 130 mg/m2 intravenous infusion≥2 h in the second day,the course was repeated every 3 weeks,the evaluations of the short term or long term and adverse reactions were evaluated after 2 cycles treatment. Results:All patients can participate in the evaluation of curative effect,and the total effective rate was 25%. The median progression free survival and median overall survival were 21.2 weeks and 52.1 weeks respectively. The main adverse reactions were toxicities and myelosuppression,non-hematologic adverse reaction was mild. Conclusions:Paclitaxel plus oxaliplatin has quite valid curative effect on the treatment of recurrent or advanced cervical cancer patients,the adverse reactions can be tolerated,which was worthy for the further clinical research.关键词
紫杉酚/有机铂化合物/宫颈肿瘤/肿瘤复发,局部/药物疗法,联合Key words
Paclitaxel/Organoplatinum compounds/Uterine cervical neoplasms/Neoplasm recurrence,local/Drug therapy,combination引用本文复制引用
田秀兰,翟建军,冯碧波,王慧香..紫杉醇联合奥沙利铂治疗复发性或晚期宫颈癌临床疗效分析[J].国际妇产科学杂志,2014,(3):304-306,3.
