国际妇产科学杂志Issue(3)：324-326,3.
滋养细胞疾病中Cyclin E及其相关蛋白的表达
Expression of Cyclin E and Its Related Proteins in Gestational Trophoblastic Disease
摘要
Abstract
Objective: To investigate the expression of Cyclin E,CDK-2 and their inhibitors P27KIP1 and P21WAF1/CIP1 in gestational trophoblastic disease (GTD). Methods:Expression of the above indexes were determined immunohistochemically by specific antibodies for these proteins on formalin-fixed paraffin sections of 30 of normal placenta tissues ,38 of hydatidiform moles and 9 of gestational trophoblastic neoplasms (GTN), including 8 invasive moles and 1 choriocarcinoma. Results:①The expression of Cyclin E and CDK-2 in GTD was significantly higher than that in normal placentas (P<0.01). The expression of P27KIP1 and P21WAF1/CIP1 in GTN was significantly lower than that in hydatidiform moles and normal placenta tissues ,respectively (P<0.05). Moreover,the expression of P27KIP1 and P21WAF1/CIP1 in hydatidiform moles which developed GTN was significantly lower than those spontaneously regressed. ②Significant negative correlations between the Cyclin E and P27KIP1,P21WAF1/CIP1 staining indexes were observed (P<0.05). There was a positive correlation between the expression of CDK-2 and Cyclin E (P<0.05). Also,the expression of P27KIP1 and P21WAF1/CIP1 showed positive correlation (P<0.05). CDK-2 showed inverse expression pattern compared with P27KIP1 and P21WAF1/CIP1,but no statistical difference was observed (P>0.05). Conclusions:Disregulation of Cyclin E/CDK-2 complex and its inhibitors participated in the development of gestational trophoblastic tumor. P27KIP1 and P21WAF1/CIP1 may be used as effective indicators for the prognosis of hydatidiform moles.关键词
妊娠滋养细胞肿瘤/细胞周期蛋白E/细胞周期蛋白依赖激酶2/P27KIP1/P21WAF1/CIP1Key words
Gestational trophoblastic neoplasms/Cyclin E/Cyclin-dependent kinase 2/P27KIP1/P21WAF1/CIP1引用本文复制引用
李娜,曲芃芃..滋养细胞疾病中Cyclin E及其相关蛋白的表达[J].国际妇产科学杂志,2014,(3):324-326,3.
