国际妇产科学杂志Issue(4)：390-394,418,6.
microRNA调控上皮-间质转化影响卵巢癌侵袭转移的研究进展
Relationship between miRNA Regulating Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer
摘要
Abstract
Ovarian cancer is a common gynecological malignancy and one of leading causes of cancer-related morbidity and mortality in female patients around the globe. The metastasis of ovarian cancer is an important factor in causing deaths. EMT (epithelial-mesenchymal transition) refers to the transition process from the phenotype of epithelial cells to mesenchymal phenotype and is closely associated with the malignant progression of tumors in its invasion and metastasis. MicroRNA (miRNA) are a class of small molecule and noncoding RNAs which inhibit translation of the mRNA transcript of the genes expression,and become more and more concerned in regulating EMT progress. Many kinds of miRNA expressed abnormally and related to the occurrence and development of ovarian cancer,are expected to be used in early diagnosis,treatment and prognosis. In this review,we presented recent research regarding the role of EMT and related microRNAs in the malignant progression of ovarian cancer.关键词
卵巢肿瘤/癌/上皮-间质转化/微RNAs/肿瘤干细胞/肿瘤转移Key words
Ovarian neoplasms/Carcinoma/Epithelial-mesenchymal transition/MicroRNAs/Neoplastic stem cells/Neoplasm metastasis引用本文复制引用
张越,张殊..microRNA调控上皮-间质转化影响卵巢癌侵袭转移的研究进展[J].国际妇产科学杂志,2014,(4):390-394,418,6.基金项目
国家自然科学基金项目（81172479）；上海市科委基础重点项目10JC1409500） （）
