雌激素跨膜受体GPR30及其在子宫内膜癌和卵巢癌中的研究进展OACSTPCD
Progress of Estrogen Trans-membrane Receptor GPR30 and Its Role in Endometrial and Ovarian Carcinomas
子宫内膜癌和卵巢癌均是女性生殖系统的恶性肿瘤，发病率呈逐年升高趋势，但发病机制尚未明了。近年发现，雌激素可介导新型G蛋白偶联受体30（GPR30）通过快速非基因转录途径调控肿瘤细胞增殖与凋亡，参与肿瘤发生发展。肿瘤相关成纤维细胞在肿瘤发展中的作用也不断受到重视。综述GPR30在子宫内膜癌及卵巢癌中的表达，分析探讨GPR30在妇科肿瘤发病机制中细胞增殖、凋亡等相关调控作用，以期为子宫内膜癌及卵巢癌的临床治疗提供新的靶点。
Endometrial and ovarian carcinomas are malignant neoplasms in the female reproductive system. Estrogen has been proved as an epidemic factor throughout gynecological carcinoma. Recently, it has been found that G-protein-coupled receptor 30 (GPR30) mediates cell proliferation and survival through nongenomic effects in hypo-exposure of estrogen. Moreover, the role of tumor associated fibroblasts in carcinoma has frequently been taken into account. We review an…查看全部>>
郑丽华;程忠平
200090 同济大学附属杨浦医院上海市杨浦区中心医院妇产科200090 同济大学附属杨浦医院上海市杨浦区中心医院妇产科
受体,G蛋白偶联癌子宫内膜肿瘤卵巢肿瘤成纤维细胞
Receptors, G-protein-coupledCarcinomaEndometrial neoplasmsOvarian neoplasmsFibroblasts
《国际妇产科学杂志》 2014 (4)
395-400,6
评论