国际妇产科学杂志Issue(4)：419-422,4.
亚临床甲状腺功能减退对妊娠期糖尿病发病及其妊娠结局的影响
Incidence of Gestational Diabetes Mellitus and Pregnancy Outcomes of Pregnant Women with Subclinical Hypothyroidism
康苏娅 1汪云 1伍理1
作者信息
- 1. 215002 江苏省苏州市，南京医科大学附属苏州医院妇产科，核医学科
- 折叠
摘要
Abstract
Objective:To explore differences in incidence of gestational diabetes mellitus (GDM) and pregnancy outcomes for patients with subclinical hypothyroidism (SCH) versus normal pregnant women. Methods:A retrospective chart review of 342 pregnant women with SCH(SCH group) and 2 605 pregnant women with normal thyroid function(control group) diagnosed by serum thyroid function screening presented for prenatal care was performed. The incidences of GDM diagnosed by oral glucose tolerance test (OGTT) of two groups were compared. Each group was divided into GDM&normal OGTT subgroups by results of OGTT, the following parameters of every subgroup were abstracted and appropriate statistical tests were performed:serum levels of TSH/FT4/TPOAb, incidences of abortion and premature delivery, the average weeks of delivery, the weights/lengths/head circumferences of neonates. Results:SCH group developed higher incidence of GDM than control group. Frequencies of TPOAb positivity were higher in SCH group than control group, while no significant differences were indicated between SCH subgroups neither was between control subgroups(P<0.01). Serum TSH level of SCH group was higher than control group while serum FT4 level was lower(P<0.01), while no significant differences of TSH and T4 levels were indicated between SCH subgroups neither were between control subgroups(P>0.05). Incidence of abortion and premature delivery in SCH-GDM subgroup was significant higher than rates in SCH-normal OGTT subgroups and both control subgroups(P<0.01). The rate was higher in SCH-normal OGTT subgroup than in control-normal OGTT subgroup (P<0.01) as well as in control-GDM subgroup than control-normal OGTT subgroup (P<0.05), while no significance difference was showed between subgroups SCH-normal OGTT and control-GDM (P>0.05). No statistical difference of the average weeks of delivery was found between SCH subgroups (P>0.05), while both were shorter than weeks of control subgroups(P<0.01). No differences were indicated in the weights/lengths/head circumferences of neonates. Conclusions: SCH increases incidence of GDM in gestation period, Risk of adverse pregnant outcomes is higher when SCH complicated with GDM because it′s more harmful than simple disease. SCH patients should be observed emphatically, specially in monitoring and controlling levels of blood sugar.关键词
甲状腺功能减退症/糖尿病,妊娠/发病率/妊娠结局Key words
Hypothyroidism/Diabetes,gestational/Incidence/Pregnancy outcome引用本文复制引用
康苏娅,汪云,伍理..亚临床甲状腺功能减退对妊娠期糖尿病发病及其妊娠结局的影响[J].国际妇产科学杂志,2014,(4):419-422,4.
