二甲双胍在合并代谢综合征的子宫内膜样腺癌中的作用及机制OACSTPCD
Effect and Mechanism of Metformin in Endometrial Adenocarcinoma Patients with Metabolic ;Syndrome
二甲双胍作为一线降糖药物,在糖尿病治疗领域发挥重要作用。代谢综合征(MS)是多种代谢物异常集结的病理状态,与其有关的远期不良结局日益受到关注。研究发现,MS各环节与子宫内膜样腺癌发病机制关系密切,两者可能存在共同的病理生理基础———胰岛素抵抗。二甲双胍具有抑制胰岛素抵抗、调节细胞因子水平及独特的抗肿瘤干细胞功能,可能发挥重要的负性调节作用,并可能成为MS人群预防及治疗子宫内膜样腺癌的新型药物。
Metformin as the first-line drugs, play an important role in the treatment of diabetes. Metabolic syndrome (MS) is a pathological condition of abnormal aggregation of multiple metabolite resulting. The long-term adverse outcomes were payed more and more attention by people. The study found, MS is recognized risk factor of endometrial adenocarcinoma, there may be a common pathophysiological basis of insulin resistance. Metformin reduces insulin re…查看全部>>
倪镌;寿华锋;楼寒梅
310022 杭州,浙江省肿瘤医院妇瘤科310022 杭州,浙江省肿瘤医院妇瘤科310022 杭州,浙江省肿瘤医院妇瘤科
二甲双胍代谢综合征X子宫内膜肿瘤治疗
MetforminMetabolic syndrome XEndometrial neoplasmsTherapy
《国际妇产科学杂志》 2014 (6)
603-605,3
浙江省医药卫生科技计划项目(2013KYB045)
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