国际妇产科学杂志Issue(6)：692-694,3.
OATP4A1、OATP2B1在妊娠期肝内胆汁淤积症胎盘表达的意义
Expression and Significance of Organic Anion Transporting Polypeptides 4A1 (OATP4A1),OATP2B1 in Placenta of ;Intrahepatic Cholestasis of Pregnancy
王会敏1
作者信息
- 1. 442000 湖北省十堰市，湖北医药学院附属太和医院产科
- 折叠
摘要
Abstract
Objective:To investigate the expression and significance of organic anion transporting polypeptides 4A1 (OATP4A1),OATP2B1 in placenta of intrahepatic cholestasis of pregnancy (ICP). Methods:Twenty pregnant women with ICP were recruited and twenty normal cesarean section patients as control groups. The expression of mRNA was analyzed by real-time PCR. Data were analyzed by the comparative threshold cycle(CT) method and the 2-△CT method was used(△CT=CT gene of interest -CT internal control). Results:The expression of OATP4A1 mRNA was higher (P<0.05) and OATP2B1 was significantly lower(P<0.01) in ICP placenta than in normal placenta. Significantly elevated cholylglycine (CG)′s level of fetal and maternal serum was associated with ICP. Conclusions:The data presented here suggests that up-regulation of transporter OATP4A1 may involve in the pathophysiology of ICP,which cause the disorder of bile acids. The expression of OATP2B1 in placenta was down-regulation in ICP. It may be involved in the disorder of estrogen metabolism in ICP ,causing the mother continued high levels of estrogen stimulation and changed sensitivity.关键词
胆汁淤积,肝内/剖宫产术/聚合酶链反应/RNA,信使/蛋白质类/雌激素类/甘胆酸Key words
Cholestasis,intrahepatic/Cesarean section/Polymerase chain reaction/RNA,messenger/Proteins/Estrogens/Glycocholic acid引用本文复制引用
王会敏..OATP4A1、OATP2B1在妊娠期肝内胆汁淤积症胎盘表达的意义[J].国际妇产科学杂志,2014,(6):692-694,3.
