中国妇幼健康研究Issue(2)：184-186,3.DOI:10.3969/j.issn.1673-5293.2014.02.004
新生儿胆红素脑病的早期诊断及神经损伤的综合评价
Early diagnosis of neonatal bilirubin encephalopathy and comprehensive evaluation of nerve injury
摘要
Abstract
Objective To analyze the sensitivity and specificity of unconjugated bilirubin ( UCB) in neonates with hyperbilirubinemia in the diagnosis of bilirubin encephalopathy .Methods UCB in cerebrospinal fluid (CSF), UCB in serum bilirubin, MRI, BAEP and NBNA of 36 neonates with hyperbilirubinemia were detected to evaluate the nerve injury and sensitive index of diagnosis in neonates with bilirubin encephalopathy.Results The level of CSF UCB in neonates with bilirubin encephalopathy was higher than that of controls (13.85 ±5.10μmol/L vs 6.12 ±4.55μmol/L), and the difference was statistically significant (t=6.888,P<0.01).The area under curve of CSF UCB (0.910) was larger than that of serum UCB (0.690) by ROC curve.When the cutoff value was 9.50μmol/L, the sensitivity was 89.0%and the specificity was 91.2%, which were higher than those of serum UCB .The incidence of MRI high signal of globus pallidus in T 1WI (77.8%) was significantly higher than that of the controls (7.9%) (χ2 =37.088, P<0.01).The abnormal rate of BAEP was 80.6%, which was significantly higher than that of the controls (18.4%) (χ2 =28.569, P<0.01).But the NBNA score was lower in than in controls (34.0 ±2.4 vs 36.6 ±2.3), and the difference was significant (t =-4.759, P <0.01).Conclusion CSF UCB can be considered as a sensitive index in the diagnosis of neonatal bilirubin encephalopathy .Neonates with bilirubin encephalopathy have high incidence of nerve injury at early stage , which needs early intervention and regular follow-up.关键词
新生儿/胆红素脑病/早期诊断/神经损伤Key words
neonate/bilirubin encephalopathy/early diagnosis/nerve injury分类
医药卫生引用本文复制引用
张健,郑洪,刘光辉,孙路璐..新生儿胆红素脑病的早期诊断及神经损伤的综合评价[J].中国妇幼健康研究,2014,(2):184-186,3.基金项目
安徽省卫生厅科研资助项目 （）
