中国妇幼健康研究Issue(2)：217-222,6.DOI:10.3969/j.issn.1673-5293.2014.02.015
宫颈上皮内瘤变锥切手术治疗对妊娠结局影响的 Meta分析
Influence of cervical conization of CIN on pregnancy outcomes:A Meta-analysis
摘要
Abstract
Objective To explore the influence of cervical conization of cervical intraepithelial neoplasia (CIN) on pregnancy outcomes and delivery outcomes.Methods Cochrane Library, PubMed, SCI and Wanfang, CNKI, CBM and other databases were searched , and hand searching of relevant journals was supplemented to search related literatures up to March 2013.Literatures were screened , extracted and assessed independently by two investigators .RevMan 5.1.7 software was used for Meta-analysis.Results Totally 11 case-control studies were recruited , including 721 cases and 5 565 controls.Meta-analysis results showed that there were no significance differences between normal people without undergoing cervical conization and young women with fertility requirement undergoing cervical conization in the incidence of cervical laceration (OR=2.15, 95%CI:0.51-9.09, P=0.30), pregnancy rate (OR=1.02,95%CI:0.59-1.76, P=0.94), delivery mode (OR=1.04,95%CI:0.86-1.27,P=0.06), and incidence of abortion (OR=1.34,95%CI:0.81-2.23, P=0.26).But the differences in the incidence of preterm birth (OR=2.16,95%CI:1.56-2.99,P<0.00001), premature rupture of membranes (OR=2.82,95%CI:1.70-4.67,P<0.00001), and low birth weight (OR=2.62,95%CI:1.62-4.24, P<0.00001) were significant .Conclusion Compared to normal population , cervical conization has no influence on postoperative pregnancy rate , mode of delivery, cervical laceration and abortion rate , but will increase the incidence of preterm birth , premature rupture of membranes and low birth weight on cervical cancer patients .关键词
宫颈上皮内瘤变/宫颈锥切术/妊娠结局/Meta分析/病例对照研究Key words
cervical intraepithelial neoplasia ( CIN)/cervical conization/pregnancy outcomes/Meta-analysis/case-control study分类
医药卫生引用本文复制引用
刘雁林,马彩玲,陈建欢..宫颈上皮内瘤变锥切手术治疗对妊娠结局影响的 Meta分析[J].中国妇幼健康研究,2014,(2):217-222,6.基金项目
国家自然科学基金资助项目（编号8110278）；自治区重大疾病医学重点实验室开放课题资助项目 （）
