摘要
Abstract
[ Abatract] Objective To explore the relationship among social factors, sex hormone levels and the high incidence of perimenopausal depressive disorder.Methods Subjects were recruited with the diagnosis criteria for depressive onset in HAMD-17 and international classification of disease-10 (ICD-10).The general data and peripheral blood samples of 79 patients with depressive disorder and those of 58 women without depressive disorder were collected to detect the levels of estrogen ( E2 ) , testosterone ( T) , progesterone ( P) , luteinizing hormone ( LH) and follicle-stimulating hormone ( FSH) with electrochemiluminescence assay.Results The incidence of sleep disorder and chronic disease in perimenopausal women with depressive disorder was higher than that in women without depressive disorder (χ2 =4.700, P=0.030;χ2 =4.866, P=0.027).The levels of E2, T, and P in the depressive disorder group were lower than those in the group without depressive disorder (z=-3.175,P=0.001;z=-3.726,P<0.000;z=-2.868, P=0.004).HAMD scores were negatively correlated with E2, T, and P levels (r=-0.284,P=0.001;r=-0.389, P=0.000; r=-0.352, P=0.000).Logistic regression analysis indicated that E2, T, and P were protective factors for the development and progression of perimenopausal depression [OR(95%CI):3.851(1.347-11.785),P=0.014;4.580(1.298-14.132),P=0.012;1.864(0.984-3.942), P=0.049].Conclusion Sleep disorder, chronic diseases and the levels of E2 , T and P are correlated with the incidence of perimenopausal depressive disorder in women. E2 , T, and P are protective factors for the development and progression of perimenopausal depression.关键词
围绝经期/抑郁症/社会因素/性激素Key words
perimenopause/depression/social factors/sex hormone分类
医药卫生
