摘要
Abstract
Objective To study the expressions of MMP-7 and MMP-26 in trophoblastic disease and their relationship with trophoblastic tumor related factors, so as to provide valuable clues for early clinical diagnosis of trophoblastic disease and determination of malignant degree.Methods The protein expressions of MMP-7 and MMP-26 in 10 cases of normal villi, 15 cases of complete hydatidiform mole, 5 cases of partial hydatiform mole, 14 cases of invasive mole and 8 cases of choriocarcinama were detected using immunohistochemistry assay ( S-ABC) for statistic analysis.Results The positive rate of MMP-7 expression in normal villi group, hydatidiform mole group, invasive mole group and choriocarcinama group was 60.000%, 45.000%, 85.714% and 100.000%, respectively, and there was significant difference (χ2 =11.011, P=0.012).Meanwhile, MMP-7 positive rate was significantly correlated with the abnormal proliferation of placental trophoblast cell (r=7.709, P=0.005).The differences between normal villi group, mole group and invasive mole group and choriocarcinoma group were significant (P <0.05).The positive rate of MMP-26 expression in normal villi group, hydatidiform mole group, invasive mole group and choriocarcinama group was 90.000%, 45.000%, 35.714%and 25.000%, respectively, and there was statistically significant difference (χ2 =9.680,P =0.021).Meanwhile, MMP-26 positive rate was significantly correlated with the abnormal proliferation of placental trophoblast cell (r=7.519, P=0.006).Group comparison of normal villi group, hydatidiform mole group, invasive mole group and choriocarcinama group was significantly different (P<0.05).Conclusion High expression of MMP-7 and low expression of MMP-26 may indicate enhanced gestational trophoblastic invasion.Detection of MMP-7 and MMP-26 expression in hydatidiform mole tissues is helpful to identify the invasive degree of hydatidiform mole.关键词
基质金属蛋白酶/基质金属蛋白酶-7/基质金属蛋白酶-26/滋养细胞肿瘤Key words
MMPs/MMP-7/MMP-26/trophoblastic tumor分类
医药卫生
