摘要
Abstract
Objective To explore the correlation among perimenopausal depression , estrogen and monoamine neurotransmitter , so as to analyze the possible pathogenesis of perimenopausal depression . Methods From October 2012 to January 2014 53 patients with perimenopausal depression admitted in gynecology and obstetrics department of Maternal and Child Health Hospital of Wuyi County were selected in observation group .Another 56 healthy perimenopausal women as the same period were selected in control group .Hamilton depression scale ( HAMD) was used to evaluate the depression status .Electrochemiluminescence immunoassay was adopted to detect the levels of estradiol (E2) and follicular hormone (FSH), and High Performance Liquid Chromatography (HPLC) was used to detect the level of plasma serotonin (5-HT) and norepinephrine ( NE).The correlation between HAMD scores and E 2 , FSH, 5-HT and NE was analyzed by pearson correlation analysis .Results The level of E 2 was significantly lower but FSH was significantly higher in the observation group than in the control group (t value was 8.616 and 6.668, respectively, both P <0.05).In the observation group 5-HT was significantly lower but NE was significantly higher than in the control group (t value was 9.030 and 4.798, respectively, both P<0.05). Pearson correlation analysis showed that total scores of HAMD were negatively correlated with E 2 and 5-HT ( r value was -0.547 and-0.387, respectively, both P <0.05), and that they were positively correlated with FSH and NE (r value was 0.488 and 0.294, respectively, both P<0.05).Conclusion Estrogen and monoamine neurotransmitters may be involved in the onset of perimenopausal depression, and they can reflect the severity of the illness in a certain extent .关键词
围绝经期抑郁症/雌激素/单胺类递质/相关性分析Key words
perimenopausal depression/estrogen/monoamine neurotransmitter/correlation analysis分类
医药卫生
