中国妇幼健康研究Issue(2)：355-356,2.DOI:10.3969/j.issn.1673-5293.2015.02.065
川崎病患儿血清25－（OH）D3及 T细胞亚群变化意义
Changes and significance of serum 25-hydroxy vitamin D3 and T cell subsets in Kawasaki disease
王娟莉 1王垒 1行海舰 1蹇强1
作者信息
- 1. 西安市儿童医院心血管内科，陕西西安 710003
- 折叠
摘要
Abstract
Objective To detect serum 25-hydroxy vitamin D3[25-(OH)D3] levels and T cell subsets in acute phase of Kawasaki disease ( KD) and to analyze the relationship between them and KD coronary artery damage as well as possible mechanisms.Methods According to echocardiography, 35 cases of KD in Xi’an Children’s Hospital were divided into coronary artery lesion (CAL) group (n=9) and non-coronary artery lesion (NCAL) group (n=26).Another 25 cases of healthy children were selected as controls.Serum 25-(OH)D3 levels at acute phase and T lymphocyte subsets were detected for data analysis.Results Serum 25-( OH) D3 level of CAL group was significantly higher than that of NCAL group (t=3.681, P=0.001).At the same time, CD4/CD8 was significantly higher in CAL group than in NCAL group (t=2.032,P=0.050).Conclusion The study shows that 25-(OH)D3 participates in KD coronary artery damage, which may due to its influence on the distribution of T cell subsets.关键词
川崎病/25-羟维生素D3/T细胞亚群/冠状动脉损伤Key words
Kawasaki disease(KD)/25-hydroxy vitamin D3[25-(OH)D3]/T cell subsets/coronary artery lesion分类
医药卫生引用本文复制引用
王娟莉,王垒,行海舰,蹇强..川崎病患儿血清25－（OH）D3及 T细胞亚群变化意义[J].中国妇幼健康研究,2015,(2):355-356,2.
