中国妇幼健康研究Issue(3)：438-439,446,3.DOI:10.3969/j.issn.1673-5293.2015.03.013
孕产妇复发性流产与胰岛素抵抗相关性Meta分析
Meta-analysis of the relationship between recurrent spontaneous abortion and insulin resistance
朱芬芳 1赵荷兰 2郑彤彤3
作者信息
- 1. 浙江省台州市三门县人民医院 中医院 妇产科，浙江 台州 317100
- 2. 浙江省温岭市第一人民医院产科，浙江 温岭317500
- 3. 浙江省台州市中心医院妇产科，浙江 台州 318000
- 折叠
摘要
Abstract
Objective To explore whether insulin resistance (IR) increases maternal recurrent spontaneous abortion (RSA) by meta-analysis of published articles at home and abroad with randomized case-control study. Methods Literatures on case-control study on relationship between RSA and IR published during the period of January 1996 to January 2014 were retrieved in PubMed, Embase, Springer link, Chinese Biomedical Literature Database with computer and other journals by hand, and they were screened with set standard and grouped for analysis. Meta-analysis was conducted for the relationship between them. Results Totally 6 articles were selected into the study. There were 432 pregnant women in RSA group and 383 cases in control group ( no abnormal pregnancy history was found) . Under the condition of no significant difference in fasting glucose level, fasting insulin value elevated and isletβ-cell function was impaired more severely in RSA group. IR index was higher in RSA group, which suggested that most of cases with IR index higher than 4. 5 were from RSA group, and the difference was significant (OR=3. 16, 95%CI:1. 7-6. 8,I2 =1. 157,P<0. 05). Conclusion IR is correlated with RSA among pregnant women, and it might be one cause of RSA.关键词
复发性流产/胰岛素抵抗/Meta分析/相关性Key words
recurrent spontaneous abortion ( RSA)/insulin resistance ( IR)/Meta-analysis/correlation分类
医药卫生引用本文复制引用
朱芬芳,赵荷兰,郑彤彤..孕产妇复发性流产与胰岛素抵抗相关性Meta分析[J].中国妇幼健康研究,2015,(3):438-439,446,3.
