摘要
Abstract
Objective To explore the influence of clinical intervention on adverse pregnancy outcomes of pregnant patients with syphilis. Methods Totally 255 pregnant patients with syphilis were divided into 4 groups according to diagnostic and treatment time of syphilis. There were 80 patients diagnosed and treated before pregnancy in pre-pregnancy intervention group, 57 patients diagnosed and treated in early pregnancy ( <16 week) in early pregnancy intervention group, 53 patients diagnosed and treated in middle gestational period ( 16 -28 week) in mid-pregnancy intervention group, and 65 patients diagnosed and treated in late pregnancy ( from 29 week to antepartum) in late-pregnancy intervention group. The incidence of adverse pregnancy outcomes was compared among different groups. Results The incidence of adverse pregnancy outcomes in late-pregnancy intervention group was significantly higher than that in mid-pregnancy intervention group (χ2 =4. 145,P <0. 05), and that in mid-pregnancy intervention group was significantly higher than that in pre-pregnancy and early-pregnancy intervention groups (χ2 value was 10. 360 and 4. 510, respectively, both P<0. 05). There was no significant difference in incidence of adverse pregnancy outcomes between pre-pregnancy intervention group and early-pregnancy intervention group (χ2 =0. 844,P>0. 05). The incidence of congenital syphilis in neonates in late-pregnancy intervention group was significantly higher than that in mid-pregnancy intervention group (χ2 =7. 707,P<0. 05), and that in mid-pregnancy intervention group was significantly higher than that in pre-pregnancy intervention group and early-pregnancy intervention group (χ2 value was 9. 827 and 6. 725, respectively, both P<0. 05). Conclusion Pregnant patients with syphilis should be treated as soon as possible to reduce the incidence of adverse pregnancy outcomes and congenital syphilis.关键词
临床干预/妊娠期梅毒/母婴传播/不良妊娠结局Key words
clinical intervention/pregnancy syphilis/mother-infant transmission/adverse pregnancy outcomes分类
医药卫生
