医学分子生物学杂志Issue(3)：183-186,4.DOI:10.3870/j.issna.1672-8009.2014.03.012
原发性高血压血压昼夜节律异常与肾损害的关系探讨
Relationship between Abnormal Circadian Rhythm of Blood Pressure and Renal Damage in Patients with Primary Hypertension
贾一平 1赵仙先1
作者信息
- 1. 上海第二军医大学附属长海医院心血管内科 上海市，200433
- 折叠
摘要
Abstract
Objective To investigate the relationship between the abnormal circadian rhythm of blood pressure and the renal damage in patients with primary hypertension .Methods A total of 154 patients with primary hypertension who were treated and underwent 24-h ambulatory blood pressure monitoring in our hospital from June 2012 to February 2014 were enrolled in this study .They were divided into four groups with 51 in dipper group , 64 in non-dipper group , 32 in anti-dipper group and 7 in deep-dipper group.The abnormal circadian rhythm of blood pressure was observed and compared among the groups.The urinary micro albumin (mALB), blood urea nitrogen (BUN), se-rum creatinine (SCr) and uric acid (UA) were detected in all patients.Results There was no sig-nificant difference in the daytime blood pressure among the four groups ( P>0.05) .The nocturnal systolic and diastolic blood pressure was significantly higher in non-dipper group , anti-dipper group and deep-dipper group than in dipper group ( P<0.05) .The 24-h pulse pressure was also signifi-cantly increased in anti-dipper group when compared with deep-dipper group ( P<0.05) .Signifi-cant difference was noted in the mALB , BUN and SCr except UA among the four groups (P<0.05) .Conclusion The abnormal circadian rhythm of blood pressure is correlated with the renal damage in patients with primary hypertension .Patients with a non-dipper, anti-dipper or deep-dipper pres-sure profile are more likely to develop early renal damage .关键词
原发性高血压/血压昼夜节律/肾损害Key words
primary hypertension/abnormal circadian rhythm of blood pressure/renal damage分类
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贾一平,赵仙先..原发性高血压血压昼夜节律异常与肾损害的关系探讨[J].医学分子生物学杂志,2014,(3):183-186,4.
