医学分子生物学杂志Issue(4)：234-239,6.
非小细胞肺癌早期诊断生物标志物的研究
Research on Biomarkers for Early Diagnosis of Non-Small Cell Lung Cancer
摘要
Abstract
Early diagnosis of non-small-cell-lung-cancer ( NSCLC ) is the key to decreasing the NSCLC-related mortality.With the advances of the quantitative analysis of circulating proteins , nucleic acids , metabolites and tumor cells , novel biomarkers with high efficacy have been identi-fied for use in the early diagnosis of NSCLC , which contributes to the clinical therapy.This study re-viewed some potential biomarkers related to the early diagnosis of NSCLC: protein markers ( con-ventional serum markers and circulating autoantibodies ) , DNA biomarkers ( mutations of oncogenes or anti-oncogenes and methylation of DNA ) , and circulating microRNAs.Combined detection of these biomarkers and other conventional detection methods may help diagnose and treat lung cancer in early time, and provide clues for the development of new gene therapy drugs.关键词
非小细胞肺癌/早期诊断/生物标志物/联合检测Key words
NSCLC/early detection/biomarker/combined detection分类
医药卫生引用本文复制引用
高燕,吴雅清,许嵘..非小细胞肺癌早期诊断生物标志物的研究[J].医学分子生物学杂志,2014,(4):234-239,6.基金项目
福建省教育厅科技项目（ No.JA12434），泉州市科技计划项目（No.2012 Z71）This work was supported by grants from the Fujian Provincial Department of Education Projects （No.JA12434） and Science and Technology Pro-ject of Quanzhou （）
