医学分子生物学杂志Issue(5)：278-282,5.DOI:10.3870/j.issn.1672-8009.2014.05.008
O6-MG-DNA-甲基转移酶基因表达调控及其与肿瘤耐药性的研究进展
Research Advances in the Regulation of O6-MG-DNA Methyltrans-ferase Gene Expression and Tumor Resistance
摘要
Abstract
DNA damage and repair play an important role in gene mutations , tumorigenesis and cell death.DNA damage caused by alkylating agents is mainly repaired by O 6-methylguanine-DNA methyltransferase gene (MGMT) .The expression of MGMT in the cells is one of the main fac -tors responsible for the resistance of alkylating agents like temozolomide (TMZ) in tumors, and the correlation of MGMT promoter methylation with cancer risk and prognosis is also identi -fied.Understanding the mechanism of MGMT regulation can help to explore the DNA damage and re -pair and overcome the drug resistance of tumor.MGMT regulatory mechanism mainly consists of pro-moter methylation and histone acetylation , transcriptional and post-transcriptional regulation.关键词
DNA 损伤修复/O6-甲基鸟嘌呤-DNA-甲基转移酶/基因表达调控/肿瘤Key words
DNA-damage repair/O6-methylguanine-DNA methyltransferase/gene expres-sion regulation/tumor分类
医药卫生引用本文复制引用
魏丹萍,代晓丽,罗瑛,张继虹..O6-MG-DNA-甲基转移酶基因表达调控及其与肿瘤耐药性的研究进展[J].医学分子生物学杂志,2014,(5):278-282,5.基金项目
国家自然科学基金（ No．81260501），云南省应用基础研究计划重大项目（No．2013FC006）@@@@This work was supported by grants from the National Natural Science Foundation of China （No．81260501） and Key Projects of Applied Basic Research Plan of Yunnan Province （）
