医学分子生物学杂志Issue(6)：347-349,3.DOI:10.3870/j.issn.1672-8009.2014.06.007
胸腺肽 a1对老年脓毒血症患者免疫功能的影响
Influence of Thymosin alpha 1 on Immune Function of Elderly Pa-tients with Sepsis
樊举兵 1夏明成 2滕晓琨3
作者信息
- 1. 南京江北人民医院药剂科 南京市，210048
- 2. 南京江北人民医院呼吸科 南京市，210048
- 3. 南京江北人民医院消化科 南京市，210048
- 折叠
摘要
Abstract
Objective To investigate the changes of cellular immune function in elderly pa-tients with sepsis, and observe the therapeutic effect of thymosin alpha 1. Methods A total of 120 elderly patients with sepsis were randomly divided into two groups: intervention group and control group (60 in each group) . Conventional therapy was adopted in the control group. Thymosin alpha 1 at 1 1. 6mg/ d was subcutaneously given to patients for 1 weeks in the intervention group based on the conventional therapy. The cellular immune function before and after treatment, APACHE Ⅱscore and in-hospital mortality were compared between the two groups. Results There were no sig-nificant differences between two groups in CD4 + , CD8 + , CD4 / CD8 + , and APACHE Ⅱ score be-fore treatment (P ﹥ 0. 05) . After treatment, CD4 + and CD4 + / CD8 + were significantly increased (P ﹤ 0. 001), but CD8 + decreased obviously in the intervention group as compared with control group (P ﹤ 0. 001). APACHE Ⅱ score and in-hospital mortality were lower in the intervention group than in the control group (P ﹤ 0. 05) . Conclusion The cellular immune function of elderly patients with sepsis is impaired significantly. Thymosin alpha 1 can profoundly improve the clinical therapeutic outcomes of such patients by increasing their cellular immune function.关键词
老年人/脓毒血症/细胞免疫功能/胸腺肽Key words
elderly/sepsis/cellular immune function/thymosin分类
医药卫生引用本文复制引用
樊举兵,夏明成,滕晓琨..胸腺肽 a1对老年脓毒血症患者免疫功能的影响[J].医学分子生物学杂志,2014,(6):347-349,3.
