国际口腔医学杂志Issue(4)：418-423,6.DOI:10.7518/gjkq.2014.04.012
脂肪干细胞及其向成骨细胞分化的调控机制
Adipose-derived stem cells and their importance to the regulatory mechanism of osteoblast differentiation
摘要
Abstract
In addition to containing some fat cells, connective tissue matrix, nerve tissues, blood vessels, and immune cells in adipose tissue, some multipotent stem cells have the potential of fat cells, osteoblasts, cartilage cells, muscle cells, endothelial cells, hematopoietic cells, liver cells, and neuronal cell differentiation. Adipose tissues can secrete polypeptide materials, such as adiponectin proteins, leptin, resistance proteins, and tumor necrosis factor. Leptins can mediate signal transduction between osteogenesis and adipogenic differentiation, thereby enhancing cell proliferation, osteogenetic differentiation ability, and mineralized nodule number. Leptins can also prevent cells from differentiating into adipocytes. The differentiation process of osteogenesis produces extracellular matrix proteins and osteogenesis-related factors, such as core factor-α1, osteoblast-specific transcription factor, collagen type 1, alkaline phosphatase, osteocalcin, bone sialoprotein, and osteopontin. By determining the gene expression patterns, the mature state of osteoblast differentiation of stem cells can be investigated. Exogenous factor regulation, gene engineering regulation, and physical methods have been used to improvethe osteogenetic differentiation ability of adipose stem cells. In addition, some researchers have employed the method of biomechanics. Detailed research on adipose stem cells can provide useful insights into bone defect repair.关键词
脂肪干细胞/骨组织工程/成骨分化Key words
adipose stem cell/bone tissue engineering/osteogenetic differentiation分类
生物科学引用本文复制引用
唐宇欣,金晗,史册,朱阳,王丹丹,王贺,林崇韬,孙宏晨..脂肪干细胞及其向成骨细胞分化的调控机制[J].国际口腔医学杂志,2014,(4):418-423,6.基金项目
国家自然科学基金（81271111）；国家自然科学基金重大合作研究计划 （）
