国际口腔医学杂志Issue(6)：635-638,4.DOI:10.7518/gjkq.2014.06.004
阻塞性睡眠呼吸暂停综合征对大鼠牙周组织影响的研究
Influence of obstructive sleep apnea syndrome on rats’ periodontium
柴晶 1王小琴 1苗伟1
作者信息
- 1. 山西医科大学第一医院正畸科 太原 030001
- 折叠
摘要
Abstract
Objective This study aims to establish the obstructive sleep apnea syndrome(OSAS) animal model in rats with periodontitis and to explore the correlation between OSAS and periodontitis. Methods Twenty SD rats were randomly divided into the control group(group A) and intermitted hypoxia exposure group(group B). The oxygen concentration in the cabin ranged from 10%±0.5% to 21%±0.5% through the circular input of oxygen and nitrogen for 8 h daily. Each SD rat received wire ligatures around the cervix of the left second maxillary molar, whereas the contralateral tooth was untreated as control. The rats were sacrificed after right weeks. X-ray and histological examination were used to evaluate the periodontal breakdown. Results The periodontal depth, sulcular bleeding index, and alveolar bone loss of the ligatured teeth significantly increased, especially in group B. Conclusion Intermittent hypoxia can aggravate periodontal inflammation and may also be a risk factor for periodontics.关键词
阻塞性睡眠呼吸暂停综合征/牙周炎/大鼠/动物模型Key words
obstructive sleep apnea syndrome/periodontics/rats/animal model分类
医药卫生引用本文复制引用
柴晶,王小琴,苗伟..阻塞性睡眠呼吸暂停综合征对大鼠牙周组织影响的研究[J].国际口腔医学杂志,2014,(6):635-638,4.
