国际口腔医学杂志Issue(6)：712-715,4.DOI:10.7518/gjkq.2014.06.023
细胞周期依赖性激酶抑制蛋白和激酶抑制蛋白及其与口腔疾病
Cyclin-dependent kinase inhibitor protein and kinase inhibitor protein and oral diseases
摘要
Abstract
Cell cycle and programmed cell death are closely related to the development of oral diseases. Cyclins, cyclin-dependent kinase(CDK), and cyclin-dependent kinase inhibitor are the major important moleculars for the regulation of cell cycle. Cyclin-dependent kinase inhibitor protein(CIP) and kinase inhibited protein(KIP) are constituted by P21, P27, and P57, which are involved in regulating cell cycle, cell death programming, and inhibiting the activity of CDK. Most of the tissue destruction of oral disease is caused by pathogens that disturb host cell proliferation and programmed cell death. The reduced or absent expression of CIP and KIP leads to junctional epithelium thickening, leukoplakia with epithelial dysplasia, and uncontrolled proliferation of tumor cells. Therefore, CIP and KIP plays an irreplaceable role in the regulation of gingival epithelial cell proliferation, the maintenance of periodontal tissues, and the expression level and activity of their work as an important target of canceration of oral leukoplakia and the progression and prognosis of tumors. This article focuses on the composition and function of CIP and KIP and the relationship between CIP-KIP and oral disease.关键词
细胞周期依赖性激酶抑制蛋白/激酶抑制蛋白/细胞周期/程序性细胞死亡Key words
cyclin dependent kinase inhibiting protein/kinase inhibited protein/cell cycle/programmed cell death分类
生物科学引用本文复制引用
刘俊超,潘亚萍..细胞周期依赖性激酶抑制蛋白和激酶抑制蛋白及其与口腔疾病[J].国际口腔医学杂志,2014,(6):712-715,4.基金项目
国家自然科学基金 （）
