国际口腔医学杂志Issue(4)：492-495,4.DOI:10.7518/gjkq.2015.04.029
Toll样受体2和4在细胞成骨向分化中的作用
Role of Toll-like receptor 2 and Toll-like receptor 4 in osteoblastic differentiation
摘要
Abstract
Toll-like receptor(TLR) 4, which mediates immunity to grand negative bacteria, is the first-identified TLR family member. TLR2 recognizes many pathogen-associated molecular patterns and responds to lipopolysaccharide stimuli with TLR4. TLR2 and TLR4 have been confirmed to regulate the osteogenesis of some cells. For example, TLR2 and TLR4 participate in aortic valve calcification through the upregulation of osteogenic differentiation in human aortic valve interstitial cells. TLR2 and TLR4 can also improve coronary atherosclerosis by increasing the expression of bone morphogenetic protein 2 in coronary artery endothelial cells, and they are involved in the osteogenic differentiation of bone marrow stromal cells. In dental pulp tissue, odontoblast-like cells, which express TLR4, migrate to damaged zones of odontoblasts and form reparative dentin. Both TLR2 and TLR4 regulate the expression of inflammation factors and odontoblastic differentiation when damage occurs. Thus, the regulation mechanism of TLR2 and TLR4 in osteogenic differentiation needs to be studied further.关键词
Toll样受体2/Toll样受体4/成骨向分化Key words
Toll like receptor 2/Toll like receptor 4/osteoblastic differentiation分类
生物科学引用本文复制引用
黄奕华,凌均棨..Toll样受体2和4在细胞成骨向分化中的作用[J].国际口腔医学杂志,2015,(4):492-495,4.基金项目
卫生部临床学科重点项目 （）
