国际医学放射学杂志2015，Vol.38Issue(3)：209-211,3.DOI:10.3874/j.issn.1674-1897.2015.03.L0302
99Tcm-MIBI显像在非霍奇金淋巴瘤化疗疗效评价中的价值
The clinical value of the 99Tcm-MIBI scintigraphy in predicting the chemotherapy response of non-Hodgkin's lymphoma
王健 1朱湘 1徐文贵 1周雯2
作者信息
- 1. 天津医科大学肿瘤医院 国家肿瘤临床医学研究中心 天津市"肿瘤防治"重点实验室 分子影像及核医学诊疗科,天津300060
- 2. 天津市临床药物关键技术重点实验室 天津医科大学药学院
- 折叠
摘要
Abstract
Objective To investigate the usefulness of 99Tcm-MIBI scintigraphy in assessing the chemotherapy response, predicting prognosis of non-Hodgkin's lymphoma. Methods Twenty patients underwent early (10 min) and delayed (120 min) 99Tcm-MIBI scintigraphy before and after chemotherapy. The early uptake rate (EUR), delay uptake rate (DUR), and washout rate (WR%) were calculated. Clinical response was assessed. The average follow-up time was 34 months. Results After chemotherapy, 8 patients showed complete remission (CR) with 99Tcm-MIBI negative and 12 patients had positive imaging. 4 of them presented partial remission (PR), 2 were in stable disease (SD) and 6 were in progressive disease (PD). Patients were divided into two groups, 12 in partial or complete response (CR+PR)and 8 in stable or progressive disease (SD+PD)group. There was statistically difference in DUR before and after chemotherapy in all the 20 patients (2.9 ±1.2 vs. 1.2 ±0.7, P＜0.05). Before chemotherapy,the DUR was significantly higher in partial or complete response group than that in stable or progressive disease group (2.9±1.2 vs. 1.5±0.9, P＜0.05). The WR% was significantly lower in partial or complete response group than that in stable or progressive disease group (21.9±2.4 vs. 42.7±50.6, P＜0.05). After chemotherapy the DUR was significantly lower in partial or complete response group than that in stable or progressive disease group (1.0±0.2 vs. 2.0±0.3, P＜0.05). Conclusion As a functional imaging, 99Tcm-MIBI scintigraphy is helpful in assessing the chemotherapy response andpredicting prognosis of non-Hodgkin's lymphoma.关键词
非霍奇金淋巴瘤/化学疗法/预后/MIBI/核素显像Key words
Non-Hodgkin's lymphoma/Chemotherapy/Prognosis/MIBI/Radionuclide imaging引用本文复制引用
王健,朱湘,徐文贵,周雯..99Tcm-MIBI显像在非霍奇金淋巴瘤化疗疗效评价中的价值[J].国际医学放射学杂志,2015,38(3):209-211,3.
