临床与病理杂志2015，Vol.35Issue(3)：395-398,4.DOI:10.3978/j.issn.2095-6959.2015.03.013
血清CA19-9、CEA水平与胰腺癌预后的关系
Relationship between serum CA19-9, CEA levels and prognosis for patients with pancreatic cancer
摘要
Abstract
Objective:To explore the use of preoperative CA19-9 and CEA serum levels as prognostic factors to affect survival in pancreatic cancer.Methods:A retrospective review of the clinical records of 128 patients with pancreatic adenocarcinoma between January, 2012 and December, 2013 was performed. Kaplan-Meier method, log-rank test and Cox regression analysis models were used to investigate the relationship between the levels of CA19-9 and CEA and survival outcome. The cut-off for CA19-9, CEA was 39 U/mL and 4.7 ng/mL. Results:The mean age of 128 patients was 62 years, and the median survival time was 12.2 months. The positive rate of CA19-9 and CEA were respectively 78.1%, 37.5%. Patients with high CA19-9 or CEA levels suffered a poorer prognosis than the individuals with normal levels (CA19-9,P=0.027; CEA,P=0.036). Cox logistic analysis revealed that lymphatic metastasis, CA19-9 >39 U/mL and CEA >4.7 ng/mL were independent prognostic factors. Conclusion:The serum levels of preoperative CA19-9 and CEA were signiifcant associated with survival time of pancreatic cancer patients, and could evaluate the prognosis of these patients.关键词
胰腺癌/CA19-9/CEA/预后Key words
pancreatic cancer/CA19-9/CEA/prognosis引用本文复制引用
吴蕾,黄珮珺,王芳,李大千,谢而付,张燕,潘世扬..血清CA19-9、CEA水平与胰腺癌预后的关系[J].临床与病理杂志,2015,35(3):395-398,4.基金项目
国家自然科学基金(81371894,81302531,81272324,81201359,81101322) （81371894,81302531,81272324,81201359,81101322）
江苏省实验诊断学重点实验室(XK201114) （XK201114）
江苏高校优势学科建设工程基金项目.This study was supported by National Natural Science Foundation of China (81371894, 81302531, 81272324, 81201359, 81101322), Key Laboratory for Laboratory Medicine of Jiangsu Province of China (No. XK201114), a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions, P. R. China. （81371894, 81302531, 81272324, 81201359, 81101322）
