摘要
Abstract
Objective:To study the effects of montelukast tablets combined with budesonide on inlfammatory factors and airlfow limitation in children with bronchial asthma.Methods: A total of 100 cases of children with bronchial asthma admitted into the hospital from August 2012 to April 2014 were chosen as the research object and were divided into two groups by the random number table method. hTe control group was treated with simple budesonide atomization inhalation while the treatment group with oral montelukast tablets on the basis of the control group. The clinical curative effect, the pulmonary function before and after the treatment, airway obstruction and the main indicators of inlfammatory cytokines of the two groups were compared.Results: hTetotal effective rate of the treatment group was 96%. Compared with 80% of the control group, the difference was statistically signiifcant (P<0.05). hTe comparison of FVC [(3.35±0.45) vs. (2.78±0.37) L], PEER [(6.76±0.51) vs. (5.21±0.45) L·s–1] and FEV1 [(2.83±0.32) vs. (2.21±0.36) L] of the two groups after the treatment was statistically significant (P<0.01). In addition, IL-6, TNF-α, hs-CRP, R5, R5-R20 and R5-R10 of the treatment group a week before and atfer the treatment were signiifcantly lower than those of the control group (P<0.01). Conclusion: Montelukast tablets combined with budesonide can obviously improve the patients’ airway inflammatory reactions, promote the recovery of pulmonary function and the curative effect is definite. The treatment can be used as an important means of treating bronchial asthma in children.关键词
顺尔宁/布地奈德/支气管哮喘/炎症因子/肺功能Key words
montelukast tablets/budesonide/bronchial asthma/infammation factors/pulmonary function
