临床与病理杂志Issue(6)：1130-1136,7.DOI:10.3978/j.issn.2095-6959.2015.06.051
食管鳞状细胞癌组织中miR-21与ERK1/2表达及临床意义的研究
MiR-21 and ERK1/2 expression and the clinical sense in esophageal squamous carcinoma
摘要
Abstract
Objective: To explore the expression of miR-21 and ERK1/2 in esophageal squamous carcinoma (ESCC) tissue and the clinical signiifcance.Methods:MiR-21 and ERK1/2 expression in 80 cases of ESCC tissues and adjacent normal tissues were detected by in situ hybridization and immunohistochemical methods respectively. Relationship between miR-21, ERK1/2 and clinicopathological parameters of 80 cases of ESCC was analysed by Spearman analysis.Results: MiR-21 and ERK1/2 expression rate and number were signiifcantly higher than that of adjacent normal tissue, especially in the ESCC tissues of lymph node metastasis, but have no statistical signiifcance in different gender, age, nationality, ESCC pathological type, tumor invasion and tumor size. Further analysis found that miR-21 expression had obvious positive correlation with p-ERK1/2 in ESCC, the correlation coeffcient is 0.570.Conclusion:MiR-21 and p-ERK1/2 are closely related to the occurrence and developmentof ESCC, the two key moleculars may be coordinated to promote malignant degree of ESCC by lymph node metastasis.关键词
食管鳞状细胞癌/miR-21/ERK1/2Key words
esophageal squamous cell carcinoma/miR-21/ERK1/2引用本文复制引用
刘凤霞,杨文清,李建勇,刘文亚..食管鳞状细胞癌组织中miR-21与ERK1/2表达及临床意义的研究[J].临床与病理杂志,2015,(6):1130-1136,7.基金项目
新疆自治区科技厅面上项目(2012211A080)。@@@@Te work was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region, General Program (2012211A080), P. R. China （2012211A080）
