临床与病理杂志Issue(7)：1371-1375,5.DOI:10.3978/j.issn.2095-6959.2015.07.032
2型糖尿病肾病患者血清及尿液PEDF水平及意义
Significance of serum and urine pigment epithelium-dirived factor in type 2 diabetic nephropathy
摘要
Abstract
Objective:To investigate the change of serum and urine pigment epithelium derived factor (PEDF) in type 2 diabetic nephropathy (DN), and to explore the signiifcance of PEDF in the development of diabetic nephropathy.Investigate whether PEDF could be an early diagnosis marker in DN. Methods:ELISA was used to detect the serum and urine PEDF in 30 healthy controls (NC group) and 90 type 2 diabetic patients, including 30 with normal albumin excretion rate (DM group), 30 with microalbumin (DN III group), and 30 with overt diabetic nephropathy (DN IV group), fasting plasma glucose (FPG). Glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), low density liloprotein cholesterol (LDL-C), serum creatine (sCr), blood urea nitrogen (BUN), 24h-urinary albumin excretion (24hUAlb), were simultaneously determined. Results:The serum PEDF levels of NC, DM, DNⅢ, DNⅣgroups were (5.51±0.24, 6.27±0.52, 8.85±0.68, 12.44±0.87μg/mL). hTe serum PEDF of type 2 diabetes mellitus (T2DM) patients was signiifcantly higher than that of the NC group and elevated gradually with the progression of DN (F=13.07, P<0.05). hTe urine PEDF levels of NC, DM, DNⅢ, DNⅣgroups were (4.98±0.21, 5.20±0.18, 6.29±0.46, 8.63±0.85μg/mL). The urine PEDF of T2DM patients was signiifcantly higher than that of the NC group and elevated gradually with the progression of DN (F=20.52, P<0.01). Correlation analysis demonstrated thatserum and urine PEDF levels were positively correlated with UAER (r1=0.880, P<0.01);(r2=0.809, P<0.01). Conclusion:The serum and urine PEDF levels significantly increases in type 2 diabetic patients, and the magnitude of PEDF is related to the severity of diabetic nephropathy. hTe increase of PEDF may involve in the development of diabetic nephropathy. PEDF in serum and urine may play an important role in the early identiifcation of diabetic nephropathy.关键词
色素上皮衍生因子/2型糖尿病/糖尿病肾病/氧化应激Key words
pigment epithelium-derived factor/type 2 diabetes mellitus/diabetic nephropathy/oxidative stress引用本文复制引用
刘珊,曹卫广,张风仪,刘赞朝..2型糖尿病肾病患者血清及尿液PEDF水平及意义[J].临床与病理杂志,2015,(7):1371-1375,5.基金项目
2013年河北省科技厅科技支撑项目(12277795)@@@@This work was supported by Science and Technology Support Project of Hebei Province (12277795), P. R. China （12277795）
