神经损伤与功能重建Issue(3)：233-235,3.DOI:10.3870/sjsscj.2014.03.020
首发精神分裂症患者威斯康星卡片分类测验中的脑功能障碍研究
Brain Dysfunction during the Performance of Wisconsin Card Sorting Test in First -episode Schizophrenia Patients
舒畅 1肖玲 1王熇生 1王惠玲 1王高华1
作者信息
- 1. 武汉大学人民医院精神卫生中心武汉 430060
- 折叠
摘要
Abstract
ObjectiveTo explore the characteristics of cerebral activation during the performance of Wisconsin card sorting test (WCST) in newly-developed schizophrenic patients without drug therapy. Methods: Twenty healthy subjects (control group) and twenty schizophrenic patients (patients group) underwent functional MRI (fMRI) during the performance of WCST and Color card sorting test (CCST). The active volume of the interested brain areas were compared between the 2 groups. Results: The images subtracted the functional images of CCST from those of WCST in the control group suggested that activations were mainly localized in the bilateral frontal lobes, especially in the dorsolateral prefrontal cortices, posterior parietal cortices and anterior cingulate gyry. The performance of WCST in the schizophrenic group were significantly lower than that in the healthy group ( <0.01). The patients showed less activations in the left dorsolateral prefrontal cortex, and left anterior cingulated, but more activations in the left posterior parietal cortex, relative to the controls ( <0.01 or 0.05). Conclusion: The bilateral frontal lobes, especially the dorsolateral prefrontal cortices, anterior cingulate gyri and posterior parietal cortices are involved in higher cognitive components of performance of WCST. Schizophrenic patients have executive function disorder at the initial stage of the disease. Evidences from fMRI indicate that the brain areas of patients including the left dorsolateral prefrontal cortex and left anterior cingulate are hypoactivative and hypofunctional whereas the posterior parietal cortices are hyperactive. The dysfunction of the prefrontal cortices and anterior cingulate cortices may be associated with the executive function disorder in schizophrenia. The hyperactivity of the posterior parietal cortices may compensate the hypofrontality to certain degree.关键词
精神分裂症/功能性磁共振/威斯康星卡片分类测验/前额叶皮质Key words
schizophrenia/functional MRI/Wisconsin card sorting test/prefrontal cortex分类
医药卫生引用本文复制引用
舒畅,肖玲,王熇生,王惠玲,王高华..首发精神分裂症患者威斯康星卡片分类测验中的脑功能障碍研究[J].神经损伤与功能重建,2014,(3):233-235,3.
