高校化学工程学报Issue(5)：1126-1131,6.DOI:10.3969/j.issn.1003-9015.2014.05.029
可注射PLLA-mPEG水凝胶的制备及性能研究
Preparation and Properties of Injectable PLLA-mPEG Hydrogel
摘要
Abstract
The star-shaped poly-L-lactide (PLLA) was synthesized via ring-opening polymerization of L-lactide using pentaerythritol as the initiator. A series of star-shaped PLLA-mPEG copolymers were synthesized from the carboxylated star-shaped PLLA and mPEG by the"core first"method. Their composition, structure, and molecular weight were characterized via 1HNMR and GPC techniques. The sol-gel transition temperatures were determined with the test tube inverting method, which was from 20 to 66°C. Phase-change characteristics of the copolymers strongly depended on the molecular weight of mPEG. The sol-gel transition temperatures increased with larger molecular weight of mPEG. When the molecular weight of mPEG was 350, the copolymer have desirable sol-gel transition temperatures between 20 and 45℃. DLS and dye probe techniques were employed to identify the formation of micelles of copolymers in aqueous solutions, which was driven by hydrophobic force. The in vitro study of drug release indicated that the Urapidil Hydrochloride-PLLA-mPEG hydrogels exhibited significant sustained-release capability, and its release kinetics could be described by the first order equation.关键词
可注射水凝胶/药物释放/聚乳酸-聚乙二醇单甲醚共聚物/盐酸乌拉地尔Key words
injectable hydrogel/drug release/PLLA-mPEG copolymer/Urapidil hydrochloride分类
化学化工引用本文复制引用
郝红,王君莲,林根尧..可注射PLLA-mPEG水凝胶的制备及性能研究[J].高校化学工程学报,2014,(5):1126-1131,6.基金项目
人事部留学人员科技活动择优资助项目(SLZ2009011) （SLZ2009011）
陕西省教育厅专项科研计划(12JK0587)。 （12JK0587）
