高校化学工程学报Issue(1)：170-176,7.DOI:10.3969/j.issn.1003-9015.2015.01.026
2-甲基-4-氨基-6-硝基间苯二酚盐酸盐的合成研究
Synthesis of 4-Amino-2-Methyl-6-Nitroresorcinol Hydrochloride
摘要
Abstract
A new synthetic process of 4-amino-2-methyl-6-nitroresorcinol (2-MANR.HCl) as the key intermediate of polymethylbenzoxazole (MPBO) was studied. 2-Methyl-resorcinol (2-MR) was used as a raw material. A mathematical model for studying yield and influencing factors of above synthetic process was established via secondary orthogonal regression and variance analysis, and optimal conditions for 2-MANR⋅HCl preparation were obtained. The results show that 2-MDNR synthesis with 92.15% yield and 99.92% purity can be obtained under the optimized condition, and the yield and purity of 2-MANR.HCl are 73.71% and 98.71%, respectively. The structure of 2-MDNR and 2-MANR.HCl was confirmed by IR, NMR, and MS. 2-MANR.HCl is a new compound and its synthesis method is not reported in the literature.关键词
2-甲基-4,6-二硝基间苯二酚/2-甲基-4-氨基-6-硝基间苯二酚盐酸盐/合成/PBO/回归正交Key words
2-methyl-4,6-binitroresocinol/4-amino-2-methyl-6-nitrobenzene-1,3-diol/synthesis/PBO/orthogonal regression分类
化学化工引用本文复制引用
吴纯鑫,吴秋萍,赵德明,张建庭,金宁人..2-甲基-4-氨基-6-硝基间苯二酚盐酸盐的合成研究[J].高校化学工程学报,2015,(1):170-176,7.基金项目
江苏省科技支撑计划项目(BE2011129)；浙江省生物燃料得用技术研究重点实验室项目(2010E10003)；浙江省教育厅基金资助项目(Y201121211)。 （BE2011129）
