广西科学Issue(2)：148-152,5.
榕树须醇提取物对脑血栓形成和凝血功能的影响
Effects of Alcohol Extract Substances from the Aerial Roots of Ficus microcarpa on Cerebral Thrombosis and Coagulation
摘要
Abstract
Objective]This study observed the effects of different extract substances from the aerial roots of Ficus microcarpa on coagulation,as well as the effect on cerebral thrombosis.[Methods]The mice model of cerebral thrombosis was induced by collagen protein and the rat thrombotic model was induced by electric stimulation,which were used to examine the effects of extract substances on the protective rate of mice cerebral thrombosis and rat thrombotic for-mation,respectively.The mice model of blood stasis was established by combined application of epinephrine with ice bath,which was used to observe the influences of the compounds on thrombin time and fibrinogen time.[Results]Different extract substances from 95% ASARFM (alcohol-soluble substance from the aerial roots of Ficus microcarpa )or 80% ASARFM could increase the recovery rate of cerebral thrombosis in mice (20%~60%).Both acetidine-soluble extract substance and n-butanol-soluble substance had better protective effect on the model of cerebral thrombosis by electric stimulation (P<0·01 and P <0·001),and could delay thrombin time of the mice with cold and stasis (P <0.05 and P <0.001 );N-butanol-soluble substance could delay fibrinogen time of the mice with cold and stasis (P <0.05).[Conclusion]N-butanol-soluble substance extracted from 80% ASARFM had better protective effect on the model of cerebral thrombosis and could improve the coagulation of mice.关键词
榕树须/凝血酶时间/纤维蛋白原时间/脑血栓Key words
Ficus microcarpa/aerial roots/thrombin time/fibrinogen time/cerebral thrombosis分类
医药卫生引用本文复制引用
陈敬民,袁志林,吴超伟,李开双..榕树须醇提取物对脑血栓形成和凝血功能的影响[J].广西科学,2015,(2):148-152,5.基金项目
广西自然科学基金项目(2011GXNSFA018237)资助。 （2011GXNSFA018237）
