广西医科大学学报Issue(1)：56-59,4.
全麻下乌拉地尔联合硝酸甘油控制性降压对鼻内镜手术患者心率与心电图ST-T的影响
TO EXPLORE THE EFFECT URAPIDIL COMBINED WITH NITROGLYCERIN ON HEART RATE AND ECG ST-T SEGMENT DURING THE COURSE OF NASAL ENDOSCOPY FOR THE PURPOSE OF CONTROL HYPERTENSION UNDER GENERAL ANESTHESIA
摘要
Abstract
Objective:To explore the effect urapidil combined with nitroglycerin on heart rate and ECG ST-T segment during the course of nasal endoscopy for the purpose of control hypertension.Methods:We ran-domly and equally divided 60 cases nasal endoscopy patients(ASA degree Ⅰ~Ⅱ)into control group(A group)and test group(B group),we used urapidil only in A group and combined with nitroglycerin in B group. We use endotracheal incubation of general anesthesia for all the patients,and continuously moni-tored mean artery pressure(MAP),heart rate(HR),electrocardiogram(ECG),oxygen saturation of blood (SpO2 )and end tidal carbon dioxide pressure(PET CO2 )during the course of operation for four time slot, which is T0 (before anesthesia),T1 (before controlled hypotention),T2 (blood pressure stable for 20 mi-nutes)and T3 (after stopping depressurization for 20 minutes).For the tow groups,we control pressure to the level of 70 percent of basis blood pressure.We recorded the changes of MAP,ST-T segment,SPO2 , operation time,blood lose,urine volume and the dosage of nitroglycerin before depressurization,blood pressure stable for 20 minutes and after stopping depressurization for 20 minutes.Results:In A group,all patient HR is higher than that before operation,and there appeared change of ST-T segment in 1 1 cases, which recovered after stopping depressurization for 20 minutes.But in B group ,there appeared no changes of ST-T segment,HR after blood pressure stable for 20 minutes is lower than that of A group,and dosage of nitroglycerin are lower than that of A group,which have statistical significance.there was no difference of blood lose and operation time between in two group (P>0.05).Conclusion:It is safe and effective to control hypertension of urapidil combined with nitroglyc-erin in FESS,and with advantage of no heart function change,stable hemodynamic with no significant change on ECG ST-T.关键词
乌拉地尔/硝酸甘油/功能性鼻内镜术/控制性降压/心率/心电图 ST-T改变Key words
Urapidil/nitroglycerin/functional endoscopic sinus surgery/control hypertension/HR/chang on ECG ST-T分类
医药卫生引用本文复制引用
黎哲敏,付小春,包陈娟,宁素梅,肖祥礼,尹红娟,赵艳,毛斯坦..全麻下乌拉地尔联合硝酸甘油控制性降压对鼻内镜手术患者心率与心电图ST-T的影响[J].广西医科大学学报,2015,(1):56-59,4.基金项目
北海市科学技术局科研项目(No.20120600) （No.20120600）
