广西医学Issue(5)：581-584,4.DOI:10.11675/j.issn.0253-4304.2014.05.10
非小细胞肺癌外周血 LUNX mRNA 表达的临床意义
Clinical significance of LUNX mRNA Expression in Peripheral Blood of Patients with Non-Small Cell Lung Cancer
摘要
Abstract
Objective To explore the relationship between the expression of lung-specific X protein gene ( LUNX) mRNA and micrometastasis in the peripheral blood of patients with non-small cell lung cancer ( NSCLC ) . Methods Ninety patients with NSCLC ( experimental group ) included 31 cases of stageⅠ,32 cases of stageⅡand 27 cases of stageⅢA.Twenty cases of benign pulmonary disease ( benign pulmonary disease group ) and 10 healthy controls (control group) were enrolled into the study.The peripheral blood was collected from the subjects in the benign pulmonary disease group and control group before operation ,just after operation and 7 days after operation ,respectively ,the expression of LUNX mRNA in the peripheral blood was detected by RT-PCR,and a comparison of the results was conducted between two groups.Results None of LUNX mRNA was detected in the control group and benign pulmonary disease group .The positive rates of LUNX mRNA expression in the experimental group before operation ,during operation and 7 days after operation were 46.67%,65.56% and 20.00%,respectively,the positive rate of LUNX mRNA expression increased significantly during operation in contrast with that before operation ( P <0 .01 ) , the positive rate of LUNX mRNA expression decreased significantly after operation in contrast with that before operation ( P<0 .01 ) .The positive rates of LUNX mRNA expression 7 days after operation of patients with stage Ⅰ,Ⅱ and ⅢA NSCLC were 6.45%, 18.75%,37.04%,respectively,the positive rate of patients with stage ⅢA NSCLC was the highest ( P <0.05). Conclusion LUNX might be a sensitive and specific marker for micrometastasis in NSCLC .Further study is needed to formulate a individual therapy for lung cancer based on the detection of LUNX in patients with lung cancer .关键词
非小细胞肺癌/肺特异性X蛋白基因/信使mRNA/微转移Key words
Non-small cell lung cancer/Lung-specific X protein gene/Message RNA/Micrometastasis分类
医药卫生引用本文复制引用
池惠良,林志潮,伍硕允,伍金华,黄文海..非小细胞肺癌外周血 LUNX mRNA 表达的临床意义[J].广西医学,2014,(5):581-584,4.基金项目
广东省医学科研基金 （）
