广西医学Issue(5)：589-591,3.DOI:10.11675/j.issn.0253-4304.2014.05.12
早期宫颈鳞癌患者血清 miR-17的表达及其临床意义
Expression of Serum miR-17 and Its Clinical Significance in Patients with Early-Stage Squamous Cervical Cancer
摘要
Abstract
Objective To evaluate the expression of serum microRNA-17(miR-17) in the diagnosis of early-stage squamous cervical cancer ,and to explore its correlation with clinicopathologic features of the disease .Methods The level of serum miR-17 was detected in 80 patients with squamous cervical cancer and 20 healthy women by real-time RT-PCR,and its diagnostic value was analyzed by receiver operating characteristic curve (ROC curve).The relationship between the level of serum miR-17 and the clinicopathologic features of the disease was analyzed .Results The relative expression level of serum miR-17 was significantly higher in patients with early-stage squamous cervical cancer in contrast with that in normal controls (P<0.01).The area under ROC curve was 0.777 and the max Youden index was 0.5,the sensitivity and specificity were 95%and 55%,respectively ,the cut-off point was 0.858.The relative expression level of miR-17 correlated with clinical stage and pathological grade of early -stage squamous cervical cancer (P<0.05), but didn′t correlate with lymph node metastasis ,the patients′age and menopausal status (P>0.05).Lower degree of tumor differentiation ,higher clinical stage and higher level of serum miR-17.Conclusion miR-17 plays a role in the occurrence and development of squamous cervical cancer ,and it is valuable for the screening of early-stage squamous cervical cancer .关键词
宫颈鳞癌/microRNA-17/血清肿瘤标志物Key words
Squamous cervical cancer/MicroRNA-17/Serum tumor marker分类
医药卫生引用本文复制引用
丁楠,姚德生,赵珊,潘新伟,任菲..早期宫颈鳞癌患者血清 miR-17的表达及其临床意义[J].广西医学,2014,(5):589-591,3.基金项目
广西自然科学基金资助项目（2013GXNSFBA019132）；广西医药卫生科研课题 （）
