广西医学Issue(6)：707-709,3.DOI:10.11675/j.issn.0253-4304.2014.06.03
甲状腺转录因子-1在肺癌组织中的表达及临床意义
Expression and Clinical Significance of Thyroid Transcription Factor 1 in Lung Cancer Tissues
摘要
Abstract
Objective To investigate the expression and diagnostic significance of thyroid transcription factor 1( TTF-1) in lung cancer tissues .Methods The expression of TTF-1 was detected by immunohistochemical staining in 50 cases of primary lung cancer ( including 23 cases of adenocarcinoma ,14 cases of squamous carcinoma ,9 cases of small-cell lung cancer ,and 4 cases of large-cell lung cancer ) and para-carcinoma tissues as well as 21 cases of metastatic lung adenocarcinomas from digestive tract and ovaries .The diagnostic and differential diagnostic values of TTF-1 in lung cancer were assessed .Results The positive expression rates of TTF-1 were 73 .9%( 17/23 ) in adenocarcinoma ,0 in squamouse cell carcinoma,77.8%(7/9)in small-cell lung cancer tissues and 50.0%(2/4)in large-cell lung cancer tissues,0 in metastatic lung adenocarcinomas ,respectively.The positive expression rates of TTF-1 in adenocarcinoma and small-cell lung cancer tissues were higher than that in squamouse cell carcinoma tissues (P<0.05).In para-carcinoma tissues of primary lung cancer ,normal or proliferous alveolar epithelium were less staining and had fewer positive cells (<20%) .The expressions of TTF-1 were all negative in the para-carcinoma tissues of secondary lung cancer .The positive expression rate of TTF-1 in lung cancer tissues wasn′t related with patients′age,gender,tumor size,tumor location(P>0.05).Conclusion TTF-1 can be used as a specific indicator for the differential diagnosis of primary or secondary lung adenocarcinomas ,and it provides some references for the judgement of histological type of primary lung cancer .关键词
肺癌/甲状腺转录因子-1/免疫组织化学/病理分型Key words
Lung cancer/Thyroid transcription factor-1/Immunohistochemistry/Pathological type分类
医药卫生引用本文复制引用
黄克锋,冼磊..甲状腺转录因子-1在肺癌组织中的表达及临床意义[J].广西医学,2014,(6):707-709,3.基金项目
广西科学研究与技术开发计划项目 （）
