广西医学Issue(7)：895-898,4.DOI:10.11675/j.issn.0253-4304.2014.07.11
小剂量右旋美托咪定对鼾症患儿七氟醚麻醉苏醒期的影响
Effects of Low-Dose Dexmedetomidine on Snoring Children during Recovery Period of Sevoflurane General Anesthesia
摘要
Abstract
Objective To observe the effects of low-dose dexmedetomidine before anesthesia induced with sevoflurane on snoring children during recovery period of anesthesia .Methods Forty children undergoing tonsil and adenoid enucleation under general anesthesia were enrolled in a double-blind study,and they were randomly divided into experimental group and control group ,20 cases in each group .The children in the experimental group received intravenous dexmedetomidine of 0.3 μg/kg 10 minutes before induction of anesthesia ,while in the control group were injected with Ringer′s solution.Peripheral oxygen saturation (SpO2),systolic blood pressure (SBP),diastolic blood pressure (DBP), respiratory rate(RR) and heart rate(HR) were monitored and recorded at 7 time points which were before dexmedetomidine infusion(T0),5 minutes after infusion(T1),10 minutes after infusion(T2),immediately awaking time of children ( T3 ) ,1 minute after extubation ( T4 ) ,5 minutes after extubation ( T5 ) ,10 minutes after intubation ( T6 ) .The agitation and Ramsay sedation scores of the children were assessed at each time point after extubation .Results There was no significant difference in DBP,RR and SpO2 between two groups(P>0.05).SBP and HR showed a significant difference between two groups(P<0.05),SBP in the control group was significantly higher than that in the experimental group at the time points of T3 ,T4 and T5 ,and the increase of SBP in the experimental group was significantly less than that in the control group(P<0.05).HR in the control group was more than that in the experimental group at the time points of T 3 ,T4 ,T5 and T6 (P<0.05).There was significant difference in agitation and Ramsay sedation scores between two groups (P<0.05),the agitation scores(T3,T4,T5 and T6) in the control group were significantly higher than those in the experimental group (P<0.05),and the Ramsay sedation scores (T3 ,T4 ,T5 and T6 )in the control group were significantly lower than those in the experimental group(P<0.05).Conclusion Low-dose dexmedetomidine can provide good sedative effects for snoring children undergoing operation during recovery period of anesthesia ,it can inhibit the children′s agitation and reaction of extubation better during recovery period of anesthesia as well as make the hemodynamics stable .关键词
鼾症/右旋美托咪定/七氟醚/全身麻醉/苏醒期/儿童Key words
Snoring/Dexmedetomidine/Sevoflurane/General anesthesia/Recovery period/Children分类
医药卫生引用本文复制引用
舒礼佩,张光英..小剂量右旋美托咪定对鼾症患儿七氟醚麻醉苏醒期的影响[J].广西医学,2014,(7):895-898,4.基金项目
广西医药卫生科研课题 （）
